Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating
Krebs’ cycle intermediates that alter transcription of immune response genes. We extended …

Innate immunity represents the first line of defence against invading pathogens. It consists
of an initial inflammatory response that recruits white blood cells to the site of infection in an …

The NLRP3 inflammasome has an important function in inflammation by promoting the
processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death …

The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin
D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome…

The functional relevance and mechanistic basis of the effects of the pyroptosis executioner
Gasdermin D (GSDMD) on colitis remain unclear. In this study, we observed that GSDMD …

Parkinson's disease (PD) is a chronic neurodegenerative disorder that is characterized by
motor symptoms as a result of a loss of dopaminergic neurons in the substantia nigra pars …

Mutations that result in loss of function of Nod2, an intracellular receptor for bacterial
peptidoglycan, are associated with Crohn's disease. Here we found that the E3 ubiquitin ligase …

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important
inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively …

Pyroptosis is an inflammatory form of cell death executed by transmembrane pore-forming
proteins known as gasdermins and can be activated in an inflammasome-dependent or -…

Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue
damage arising from excessive inflammatory response. Whether such negative feedback …